The role of lumbar drainage in the treatment of post-neurosurgical bacterial meningitis

Not Applicable

• Conditions: central nervous system infection; nosocomial bacterial meningitis; Infection - Other infectious diseases

• Registration Number: ACTRN12613000757718
• Lead Sponsor: Ke Wang

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-07-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

(1) postoperative or post-traumatic patients with nosocomial bacterial meningitis diagnosed by clinical manifestations in combination with positive results from cerebrospinal fluid culture and/or Gram's staining; (2) No clinical or radiographic signs of impending brain herniation;(3) informed consent is obtained from family members

Exclusion Criteria

(1) Failure to obtain informed consent; (2) Patients with unremovable infected neurosurgical devices; (3) Presence of coagulation disorders or thrombocytopenia ; (4) Presence of chronic heart failure, respiratory insufficiency, liver dysfunction or renal impairment ; (5) Patients on immunosuppressors;(6) Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A cure measured by resolution of meningitis-related clinical manifestations and normalization of cerebrospinal fluid characteristics, or death due to uncontrolled bacterial meningitis[Monitored on a daily basis until reaching the primary outcome];Intracranial complications due to meningitis, including hydrocephalus and seizure. Hydrocephalus is diagnosed by clinical manifestations combined with enlarged ventricular size on computerized tomography scans. Seizure is diagnosed by clinical manifestations combined with electroencephalographic evidence.[Monitored on a daily basis until 6 months after the meningitis]

Secondary Outcome Measures

Name	Time	Method
Duration of antibiotic usage calculated by days of intravenous antibiotic administration[Monitored on a daily basis until discharge];Days of meningitis-related clinical manifestations, including fever and impaired consciousness measured by the Glasgow Coma Scale score.[Monitored on a daily basis until discharge];Days of normalization of cerebrospinal fluid characteristics, including white cell count, glucose and protein concentration, and microbial culture and Gram's staining .[Monitored on a daily basis until discharge]