Effect of positive pressure ventilation at end of expiration on non invasive technique of intracranial pressure monitoring in patients undergoing spine surgery under general anaesthesia

Recruiting

Conditions: Spinal stenosis,

Registration Number: CTRI/2021/07/034902

Lead Sponsor: Department of Anesthesiology and Critical Care JNMCH AMU Aligarh

Brief Summary: TITLE - A prospective observational study to evaluate the effect of positive end-expiratory pressure on optic nerve sheath diameter in spine surgeries done in prone position

INTRODUCTION - Mechanical ventilation in prone position and positive end-expiratory pressure are techniques used to improve oxygenation in patients with respiratory failure. However, both prone positioning and positive end-expiratory pressure can have undesirable effects on cerebral physiology and increase the intracranial pressure. In this study, we use optic nerve sheath diameter as a technique to monitor the intracranial pressure.

Thus, this study will evaluate the effect of various levels of positive end-expiratory pressure on optic nerve sheath diameter in patients undergoing spine surgeries in prone position

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 40

Inclusion Criteria

Written and informed consent Patients scheduled for elective spine surgery in prone position requiring tracheal intubation Patients with ASA grade 1 and 2.

Exclusion Criteria

Patient refusal Optic nerve diseases Orbital inury, mass or previous ocular surgery History of intracranial hypertension History of respiratory dysfunction History of thyroid disorder, hypotension,neuropsychiatric disorder Pregnancy/lactation.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study the effect of positive end-expiratory pressure on optic nerve sheath diameter in patients undergoing spine surgeries in prone position	After 10 minutes of endotracheal intubation in supine position without positive end-expiratory pressure \| After 10 minutes of prone position without positive end-expiratory pressure \| After 10 minutes of prone position with 3 cm water of positive end-expiratory pressure \| After 10 minutes of prone position with 5 cm water of positive end-expiratory pressure

Secondary Outcome Measures

Name	Time	Method
To study the effect of positive end-expiratory pressure on mean arterial pressure	After 10 minutes of endotracheal intubation in supine position without positive end-expiratory pressure

Trial Locations

Locations (1): Department of Anaesthesiology and Critical Care, JNMCH
🇮🇳
Aligarh, UTTAR PRADESH, India
Department of Anaesthesiology and Critical Care, JNMCH
🇮🇳Aligarh, UTTAR PRADESH, India
Dimpy Saikia
Principal investigator
7002033540
mandrrakes@gmail.com