Effects of Exercise on Cardiac Fat in Women With Obesity: a Pilot Study

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Other: Exercise Intervention

• Registration Number: NCT02589327
• Lead Sponsor: Texas Tech University

Brief Summary

Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.

Detailed Description

Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. More effective treatments are needed to induce changes in cardiac fat content, body composition, and cardiac fat metabolic activity that result in a reduction in cardiovascular risk in overweight and obese population. Despite this need, little is known about which mode, frequency, and duration of exercise will allow for greater reductions in cardiac fat, improvements in body composition, restoration of a healthy cardiac fat metabolic activity, and improvement on cardiovascular risk markers. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.

Study Timeline

• Status Verified: 2015-09
• Study Start: 2015-10
• Study First Submitted: 2015-10-14
• Study First Submitted QC: 2015-10-27
• Study First Posted: 2015-10-28
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Last Update Submitted: 2016-05-09
• Last Update Posted: 2016-05-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 15

Inclusion Criteria

• BMI 30-39.99
• White/Caucasian

Exclusion Criteria

• Known health problems such as cardiovascular, pulmonary or metabolic disease will be excluded.
• Pregnant females.
• Any adults found taking medications that affect endocrine or cardiovascular function will also be excluded from the study.
• Participants that exercise more than three times per week or strength train more than twice per week.
• Individuals that have poor venous access or have expressed a fear of needles or having blood taken will also be excluded.
• Cigarette smoking (current or those who quit within the previous 6 months
• Hypertension
• Diabetics
• MRI exclusion criteria must be observed: must complete a safety checklist that is designed to identify metal in your body that could pose a hazard during scanning. Some forms of metal are acceptable (e.g., dental fillings after 1970). Tattoos are generally not exclusionary, unless they have been inked with metallic dyes. All metal must be removed from your body. All female subjects, prior to scanning, are required to complete a pregnancy test. Must NOT be claustrophobic or have a history of claustrophobia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise Intervention	Exercise Intervention	Hight intensity resistance training group

Primary Outcome Measures

Name	Time	Method
Changes in Cardiac fat volumes	2 assessment points: at baseline and week 4	Cardiac fat volumes will be assessed by means of Magnetic Resonance Imaging

Secondary Outcome Measures

Name	Time	Method
Changes in Cardiorespiratory Function	2 assessment points: at baseline and week 4	Cardiorespiratory Function will be assessed on a treadmill test with a 12-lead EKG. Protocol: Modified Bruce (A baseline stage will be added)
Changes in Vascular function	2 assessment points: at baseline and week 4	Vascular function will be assessed by means of Arterial Tonometry
Changes in Muscular Strength	2 assessment points: at baseline and week 4	Muscular Strength in upper and lower extremities will be assessed by 1 repetition maximum (1RM) test on Bench Press and Leg Press
Changes in Body Composition	2 assessment points: at baseline and week 4	Body Composition will be assessed using Dual-energy x-ray absorptiometry
Changes in Diet	5 assessment points: baseline, week 1, 2, 3, and 4	Diet will be assessed using the ASA24h recall (http://epi.grants.cancer.gov/asa24/)
Changes in Spontaneous Physical Activity	Baseline and week 4	Spontaneous Physical Activity will be assessed using accelerometers Actical.
Changes in Oxidative stress markers	5 assessment points: pre-post during session 1, pre-post during session 9, and pre week 4.	Blood will be collected and processed in order to assess oxidative stress markers

Trial Locations

Locations (1)

Kinesiology and Sport Management; 🇺🇸 Lubbock, Texas, United States