Blue Light Therapy for Liver Surgery
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- Change from baseline creatinine concentration at 24 hours after surgery
研究概览
简要总结
The investigators hypothesize that subjects undergoing liver resection and who are exposed preoperatively to high illuminance blue spectrum light will exhibit reduced organ injury, specifically liver dysfunction, than subjects exposed to standard ambient white fluorescent light.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age greater than 17 years
- •undergoing right or left hepatic lobectomy
排除标准
- •presence of acute traumatic brain injury
- •blindness
- •immunosuppression or immunocompromised condition
研究组 & 干预措施
Blue light
Subjects will be exposed to 24 hours of bright (1700 lux) blue (peak 442 nm) spectrum light the day prior to operative intervention and for the 24 hours after the operative intervention.
干预措施: Blue light (Other)
Ambient light
Subjects will be exposed preoperatively to the lighting conditions of their living environment and postoperatively to the standard, white fluorescent lighting environment of the hospital.
结局指标
主要结局
Change from baseline creatinine concentration at 24 hours after surgery
时间窗: preoperatively and 24 hours after surgery
a serum marker of acute kidney injury
Change from baseline alanine aminotransferase (ALT) concentration at 24 hours after surgery
时间窗: preoperatively and 24 hours after surgery
a serum marker of acute liver injury
次要结局
- ICU length of stay(for the duration of postoperative inpatient hospital stay up to 28 days)
- Change in serum cytokine concentrations at 24 hours after surgery(24 hours after surgery)
- Ventilator-free days(for the duration of postoperative inpatient hospital stay up to 28 days)
- renal replacement therapy(for the duration of postoperative inpatient hospital stay up to 28 days)
- Change in serum cytokine concentrations at 1 hour after surgery(1 hours after surgery)
研究者
Allan Tsung
Professor
University of Pittsburgh