Community-based Actions to Tackle the Problem of Antibiotic Resistance

Recruiting

• Conditions: Factors influencing health status and contact with health services, (2) ICD-10 Condition: R00-R99||Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified,; Those having symptoms of infections, e.g., fever, productive cough, loose stool, burning micturition, during last 3 months.

• Registration Number: CTRI/2023/02/050054
• Lead Sponsor: Indian Council of Medical Research

Brief Summary

***B**a**ckground:***

Antibiotic resistance is a global threat that occurs naturally but misuse and overuse of antibiotics in humans and animals is accelerating the process and requires ‘one health’ approach to mitigate the situation.

***N**o**v**e**l**t**y:***

Considering ‘one health’ approach in the proposed study, it is the novel concept for implementation in Indian context. The proposed study would generate evidence on burden of antibiotic resistance, awareness and practices of proper antibiotic consumption among community members in West Bengal. The intervention package proposed in this study will be a novel intervention, which can be integrated with the existing healthcare delivery system as well.

***O**b**j**e******ctive****s:***

To evaluate the changes in awareness and practices related to antibiotic consumption, and the proportion of antibiotic resistance after the intervention.

***M**e**t**h**od**s:***

The proposed study will be an embedded mixed methods interventional community-based study to be conducted in greater Kolkata region and West Medinipur district among adults (≥ 18 years of age) who will give consent for participation, and residing in a particular area for more than 10 years. Intervention in the form of behavioral intervention package, targeting awareness, perceived severity, and perceived susceptibility regarding the issue of Antibiotic resistance will be developed and implemented. Data collection in the form of survey, observation, in-depth interview, collection of human, animal and environment sample will be carried out.

***E**x**pe**c**t**e**d outcome:***

The intervention package proposed is expected to improve the awareness of the participants on appropriate use of antibiotics, and on the adverse effects of antibiotic resistance.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-02-03
• Study Start: 2023-02-27

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 3800

Inclusion Criteria

Individuals suffering from any symptoms of systemic infection (e.g., fever, pain in the abdomen, diarrhea, urinary problems, cough and cold, etc.) within the last 3 months of the field survey.

Exclusion Criteria

• Critically ill, cancer patients, or bed-ridden patients 2.
• Individuals diagnosed to be immunocompromised 3.
• Individuals on immunosuppressive therapy 4.
• Respondents diagnosed with any psychiatric illness.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The intervention package proposed is expected to improve the awareness of the participants on appropriate use of antibiotics, and on the adverse effects of antibiotic resistance. It is expected that the proportion of antibiotic resistance will not increase further in the intervention clusters as compared to the control clusters.	3 months after the intervention delivery

Secondary Outcome Measures

Name	Time	Method
It is expected that the proportion of antibiotic resistance will not increase further in the intervention clusters as compared to the control clusters.	3 to 4 months after the intervention delivery

Trial Locations

Locations (3)

Kolkata (Urban); 🇮🇳 Kolkata, WEST BENGAL, India

Paschim Medinipur (Rural); 🇮🇳 Medinipur, WEST BENGAL, India

Paschim Medinipur (Urban); 🇮🇳 Medinipur, WEST BENGAL, India

Kolkata (Urban)

🇮🇳Kolkata, WEST BENGAL, India

Sweety Suman Jha

Principal investigator

8017355170

swty.jha06@gmail.com