An exploratory study to evaluate the eye movement in Parkinson disease

Not Applicable

• Conditions: Parkinson disease

• Registration Number: JPRN-UMIN000044246
• Lead Sponsor: Department of Neurology Juntendo University School of Medicine

Brief Summary

The MDS-UPDRS Part III score of PD motor symptoms, the ON/OFF score of the patient symptom diary, and the L-dopa blood concentration showed similar trends to the blink frequency. Furthermore, by extracting various parameters such as blink duration and confidence from the blink information and applying machine learning, we constructed a model to estimate clinical symptoms at the same point in time from 3 minutes of blink data. UPDRS Part III score in real time.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-18
• Study Completion: 2022-03-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up continuing
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

1.Atypical Parkinsonism syndromes 2.Dementia or at high risk of it (Mini Mental State Examination (MMSE) score < = 20) 3.Contraindicated for concomitant medications (L-DOPA / carbidopa) 4.Hypersensitivity to concomitant medications (L-DOPA / carbidopa) and/or their ingredients 5.Co-existing psychiatric disease (e.g., depression, bipolar disorder or schizophrenia) and/or clinically significant complications (e.g., cerebrovascular accident, heart disease, chronic respiratory disease, uncontrolled hypertension and diabetes) 6.History of psychiatric disease (e.g., depression, bipolar disorder or schizophrenia) and/or device-aided therapies (i.e., GPi pallidotomy, thalamotomy, and deep brain stimulation) 7.Those who are judged by the principal investigator to be inappropriate as research subjects

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Clinical evaluation scales for Parkinson disease (Hoehn-Yahr, MDS-UPDRS, UDysRS, patient diary, PDQ-39, and EQ-5D-5L) 2. Eye movement (saccadic movement, eye blinks, eye blink speed, etc.) 3. Plasma levodopa concentration