A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History.

• Conditions: Lung Neoplasms; Family Research

• Registration Number: NCT04220268
• Lead Sponsor: Guangdong Provincial People's Hospital

Brief Summary

The aim of the present prospective cohort study (GGN-F) is to study the family aggregation of pulmonary ground glass nodules via the questionnaire survey and to investigate the underlying genetic mechanism via the biobank.

Detailed Description

In recent years, with the development of low-dose chest CT screening, more and more ground glass nodules have been found. Meanwhile, presenting as Ground-glass nodule (GGN), the early-stage lung adenocarcinoma patients with lung cancer family history have been emerging increasing in recent years in East Asian.

This prospective cohort study, with both a cross-sectional and a longitudinal part, will include patients with pulmonary ground glass nodule, which were proven malignant disease.

All participants will be asked to complete questionnaire to build the clinical database of GGN patients with detailed family history. Furthermore, blood and surgical tumor samples will be collected as a specific biobank. And the blood samples of other family members of participants will be collected, with their consent and knowledge.

Study Timeline

• Status Verified: 2020-01
• Study Start: 2020-01-05
• Study First Submitted: 2020-01-05
• Study First Submitted QC: 2020-01-05
• Last Update Submitted: 2020-01-05
• Study First Posted: 2020-01-07
• Last Update Posted: 2020-01-07
• Primary Completion: 2022-01-05
• Study Completion: 2022-01-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

1. patients with informed consent;
2. patients with pulmonary ground glass nodule.
3. pathological proved early stage lung cancer.

Exclusion Criteria

1.not included in the inclusion criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The prevalence of family aggregation of pulmonary ground glass nodule.	1 week	To investigate the aggregation of pulmonary ground glass nodule among first-degree relatives of participants via the questionnaire.

Secondary Outcome Measures

Name	Time	Method
Susceptibility genetic events related to the family aggregation of ground glass nodules.	1 month	To investigate the underlying susceptibility genetic loci which concern with familial inheritance of ground glass nodule.

Trial Locations

Locations (1)

Guangdong Provincial People's Hospital; 🇨🇳 Guangzhou, Guangdong, China