The effects of preceding human endotoxemia on the Fluenz-induced immune response, a explorative study - LPS-Fluenz

Radboud Universitair Medisch Centrum0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•-Pre-existent lung disease, including asthma
•-A history of allergic rhinitis
•-Use of any medication
•-Use of alcohol > 5/day or >20/wk
•-Use of any drugs
•-Current smoker or more than 5 pack-year history
•-Frequently have nosebleeds
•-Recent nasal or otologic surgery
•-Febrile illness or a common cold within four weeks before the LPS challenge
•-Currently participating in another clinical trial or donation of blood 3 months prior to the LPS challenge.
•-Previous spontaneous vagal collapse.
•-History, signs or symptoms of cardiovascular disease.
•-(Family) history of myocardial infarction or stroke under the age of 65 years.
•-Cardiac conduction abnormalities on the ECG consisting of a 2nd degree atrioventricular block or a
•complex bundle branch block.
•-Hypertension (defined as RR systolic > 160 or RR diastolic > 90).
•-Hypotension (defined as RR systolic < 100 or RR diastolic < 50).
•-Renal impairment (defined as plasma creatinin >120 µmol/l).
•-Liver enzyme abnormalities or positive hepatitis serology.
•-Positive HIV serology or medical history of any other obvious disease associated with immune deficiency.
•-History of allergic reaction to Fluenz®, eggs / gelatin / gentamicin
•-History of Guillain-Barré Syndrome

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