Effects of oxygen status on endotoxemia induced inflammation and Hypoxia Inducible Factor 1-a. A pilot proof of principle study.

Radboud University Nijmegen Medical Centre0 个研究点目标入组 30 人开始时间: 2013年8月20日最近更新: 2020年11月30日

适应症

试验速览

暂无简介。

•-Use of any medication
•-History, signs or symptoms of cardiovascular disease
•-History of atrial or ventricular arrhythmia
•-(Family) history of myocardial infarction or stroke under the age of 65 years
•-Cardiac conduction abnormalities on the ECG consisting of a 2nd degree atrioventricular block or a complex bundle branch block
•-Hypertension (defined as RR systolic > 160 or RR diastolic > 90 mmHg)
•-Hypotension (defined as RR systolic < 100 or RR diastolic < 50 mmHg)
•-Renal impairment (defined as plasma creatinine >120 µmol/l)
•-Liver enzyme abnormalities alkaline phosphatase>230 U/L and/or ALT>90 U/L
•-Medical history of any obvious disease associated with immune deficiency
•-CRP > 20 mg/L, WBC > 12x109/L, or clinically significant acute illness, including infections, within 4 weeks before endotoxemia day
•-Participation in a drug trial or donation of blood 3 months prior to the experiment
•-Pre-existent pulmonary diseases, including asthma
•-Use of recreational drugs within 21 days prior to experiment day
•-Visit to altitude >1500m within 4 weeks prior to the experiment
•-Air travel with flight time over 3 hours within 4 weeks prior to the experiment
•-History of acute mountain sickness
•-Recent hospital admission or surgery with general anaesthesia (<3 months)
•-Claustrophobia
•-Feelings of discomfort during a 10 minute test wearing the transparent respiratory helmet at the screening visit

发起方

Radboud University Nijmegen Medical Centre