Effect of mannitol 20% on the coagulation properties and platelet function in patients with craniotomy.
- Conditions
- Platelet functionThrombelastometry
- Registration Number
- DRKS00018947
- Lead Sponsor
- Klinik für Anästhesiologie und Intensivmedizin Medizinische Hochschule Hannover
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 38
Inclusion Criteria
• Patients = 18 years, Intra-cranial procedure with the indication for the administration of mannitol (1 g per kg of body weight) given by the surgeon on the basis of the surgical site.
Exclusion Criteria
Intake of anticoagulant or antiplatelet agents without decreasing the clinical duration of the same substances (eg, ASA, Marcumar, Heparins, other NSAIDs, etc., NOACs).
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method AUC in impedance aggregometry with ADP, ASPI and TRAP (Multiplate Analyzer)
- Secondary Outcome Measures
Name Time Method • Maximum Clot Firmness (MCF) in the FibTem® test<br>• Maximum Clot Firmness (MCF) in the ExTem® test<br>• Clotting time (CT) in ExTem® and FibTem® test<br>• Clotformation Time (CFT) in the ExTem® and FibTem® tests<br>• Clottingtime (CtPFA) in the PFA-100 test<br>• International Normalized Ratio (INR)<br>• Activated partial thromboplastin time (aPTT)<br>• hematocrit<br>• platelet count