TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries
- Conditions
- Low Caries RiskHigh Caries Risk
- Registration Number
- NCT04066101
- Lead Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
- Brief Summary
The aim of this study is to examine the effects of TAS1R1, TAS1R3, TLR2, TLR4, CA6, gene polymorphism on caries risk in adults.
- Detailed Description
To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.
CA6 exists in the human saliva and has a critical role of buffering, immune response and taste.Toll-like receptors are expressed in the tongue gustatory papillae where they may initiate immune responses to pathogens.Genetic variations in the TAS1R1 and TAS1R3 for umami cause perception of these tastes differently.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- adult be between 25 and 44 years old
- subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) ≥ 5, or, DMFT ≥14
- same oral health, diet and socioeconomic status
- systemic or genetic disorders
- orthodontic appliances
- pregnant women
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Past caries experience 4 months Each tooth will be examined and recorded as decayed, missing, or filled (DMFT). Caries will be defined in accordance with the World Health Organization (WHO 1997) criteria.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (1)
Recep Tayyip Erdogan University
🇹🇷Rize, Turkey
Recep Tayyip Erdogan University🇹🇷Rize, Turkey