Brain Mechanism and Intervention of Executive-control Dysfunction Among Substance Dependents
- Conditions
- Transcranial Alternating Current StimulationSubstance DependenceExecutive Function Disorder
- Interventions
- Device: Transcranial alternating current stimulation-true stimulusDevice: Transcranial alternating current stimulation-sham stimulus
- Registration Number
- NCT05312359
- Lead Sponsor
- Shanghai Mental Health Center
- Brief Summary
The investigators assume that tACS could improve amphetamine and alcohol dependent patients' executive-control function by adjusting the synchronization patterns and enhancing the functional connectivity of the prefrontal-ventral striatum pathway. A random controlled trial will be used to test the effect of θ-tACS treatment. Three months follow-up assessment will be conducted to test the changing of executive-control function and its mechanism.
- Detailed Description
Substance abuse has become a major social and public health problem in China, especially for amphetamine abuse and alcohol abuse. Executive-control dysfunction is the main symptom for substance dependents. Previous studies have demonstrated the relationship between cognitive dysfunction and prefrontal-ventral striatum pathway. Studies have shown that abnormal phase synchronization and phase-amplitude coupling (PAC) induced the impairment of cognitive, and tACS could improve executive-control function by adjusting the abnormal synchronization. But it has not been verified among MA or alcohol patients. The investigators assume that tACS could improve MA and alcohol dependent patients' executive-control function by adjusting the synchronization patterns and enhancing the functional connectivity of the prefrontal-ventral striatum pathway. A random controlled trial will be used to test the effect of θ-tACS treatment. Three months follow-up assessment will be conducted to test the changing of executive-control function and its mechanism. This study will provide a practical and theoretical basis for developing a novel treatment for substance dependents.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 210
- Aged 18-60, male or female, with 9 or more years of education, and able to complete questionnaire evaluation and behavioral tests
- Meet DSM-5 diagnostic criteria for amphetamine-type substance addiction or alcohol addiction
- Have used amphetamine or alcohol for at least one year (at least once a week)
- Normal vision and hearing, or within the normal range after correction
- Agree to cooperate in the follow-up evaluation
- No metal implantation in the head, no history of nerve problems or head injury, and no skin sensitivity
- Have severe cognitive impairment, such as a history of head trauma, cerebrovascular disease, epilepsy, etc.
- Have used drugs promoting cognitive function in the last 6 months
- Have impaired intelligence (IQ<70)
- Abuse or dependence of other psychoactive substances (except nicotine) in the last 5 years
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Intervention group of alcohol addiction Transcranial alternating current stimulation-true stimulus A 20-minute tACS intervention of real-stimulus is conducted twice a day for a total of 10 days in the intervention group of alcohol addiction. Control group of alcohol addiction Transcranial alternating current stimulation-sham stimulus A 20-minute tACS intervention of sham-stimulus is conducted twice a day for a total of 10 days in the control group of alcohol addiction. Intervention group of amphetamine addiction Transcranial alternating current stimulation-true stimulus A 20-minute tACS intervention of real-stimulus is conducted twice a day for a total of 10 days in the intervention group of amphetamine addiction. Control group of amphetamine addiction Transcranial alternating current stimulation-sham stimulus A 20-minute tACS intervention of sham-stimulus is conducted twice a day for a total of 10 days in the control group of amphetamine addiction.
- Primary Outcome Measures
Name Time Method The change of theta(θ) phase synchronicity baseline, immediately after the intervention, one month after the intervention, three months after the intervention The change of θ phase synchronicity in the prefrontal - ventral striatum pathway in amphetamine addicts and alcohol addicts will be measured by EEG.
The change of theta-gamma phase amplitude coupling(θ-γ PAC) baseline, immediately after the intervention, one month after the intervention, three months after the intervention The change of θ-γ PAC in the prefrontal - ventral striatum pathway in amphetamine addicts and alcohol addicts will be measured by EEG.
The change of inhibitory control ability baseline, immediately after the intervention, one month after the intervention, three months after the intervention The change of inhibitory control ability will be reflected by participants' performance in the Go/No Go task.
- Secondary Outcome Measures
Name Time Method The change of working memory baseline, immediately after the intervention, one month after the intervention, three months after the intervention The change of working memory will be measured by the two-back task.
DA metabolic rate baseline DA metabolism was measured by Positron Emission Computed Tomography
The change of decision-making ability baseline, immediately after the intervention, one month after the intervention, three months after the intervention The change of decision-making ability will be measured by the Balloon Analog Risk Task.
Trial Locations
- Locations (1)
Shanghai Mental Health Center
🇨🇳Shanghai, Shanghai, China