The Sevoflurane study, understanding the effects of Sevoflurane to improve safety and outcome of cardiac surgery

Completed

• Conditions: 10046973; restoration of bloodflow after period of restriction of bloodflow; Ischemia-Reperfusion

• Registration Number: NL-OMON33476
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Patients without heart failure (EF below 35%) accepted for mitral valve surgery via sternotomy

Exclusion Criteria

Acceptation for minimal invasive mitral valve surgery, inability to sign informed consent, less than 18 years old, emergency operations

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>We want to assess the contribution of Sevoflurane on oxidative damage,<br /><br>complement, endothelial, thrombocyt and neutrophil activation and inflammation<br /><br>to human ischemia reperfusion injury. Obtained data will provide information<br /><br>about possible protection against ischemia reperfusion injury and the possible<br /><br>contribution of Sevoflurane to attenuate SIRS, leading to a decline in<br /><br>morbidity and mortality rates. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>