Metabolic Disturbances in Polycystic Ovary Syndrome (PCOS)

Completed

• Conditions: Polycystic Ovary Syndrome

• Registration Number: NCT00606671
• Lead Sponsor: Hvidovre University Hospital

Brief Summary

The scope of the study was to investigate different metabolic aspects that may lead to or are a consequence of insulin resistance in premenopausal women with polycystic ovary syndrome (PCOS). We use gold standard methods for evaluation of insulin resistance. We take muscle and fat biopsies for investigation of gene expression of different cytokines associated with insulin resistance. We investigate the incretin hormones GIP and GLP-1. These two hormones play a central role in glycemic control, and diabetic subjects are known to have alterations in their incretin hormones. The incretin hormones have not previously been investigated in women with PCOS.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-02
• Primary Completion: 2006-05
• Study Completion: 2006-05
• Status Verified: 2008-01
• Study First Submitted: 2008-01-17
• Study First Submitted QC: 2008-02-01
• Last Update Submitted: 2008-02-01
• Study First Posted: 2008-02-04
• Last Update Posted: 2008-02-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 65

Inclusion Criteria

• Premenopausal women that meet the Rotterdam criteria for PCOS (BMI < 40)
• Age and BMI matched control women that do not have any signs or symptoms of PCOS

Exclusion Criteria

• BMI > 40. mani fest diabetes or other known diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
insulin resistance	2004-2006

Secondary Outcome Measures

Name	Time	Method
gene expression of cytokines in fatty tissue	2004-2006

Trial Locations

Locations (1)

Dpt. of Obstetrics and Gynaecology, Copenhagen University Hospital, Hvidovre; 🇩🇰 Hvidovre, Denmark