Effects on the Septic Patient's Microcirculation of the Transfusion of Three Different Types of Concentrated Red Blood Cells.
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Septic Patients
- Sponsor
- Università Politecnica delle Marche
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Microcirculatory Flow Index (MFI) before and after blood transfusion.
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
Aim of the study is to evaluate the effects, on microcirculation of septic patient, of three types of RBCs: 1- fresh standard RBCs (storage <10 days); 2-leukodepleted RBCs and 3-old standard RBCs (storage >15 days) respectively. Before and 1 hour after the transfusion, microcirculation is evaluated using Sidestream Dark Field Imaging (SDF) and Near InfraRed Spectroscopy (NIRS) with vascular occlusion test. We also monitor temperature, heart rate, mean blood pressure, hemochrome, blood gases, blood lactates and SOFA score.
Investigators
Abele Donati, MD
Associate Professor
Università Politecnica delle Marche
Eligibility Criteria
Inclusion Criteria
- •Patients with sepsis, severe sepsis or septic shock who, according to clinical evaluation, need a hemotransfusion.
Exclusion Criteria
- •Patients under 18 years of age; Pregnancy; Coagulative disorders; Cardiogenic shock (Met\<4;)Acute massive bleeding (\>8 U)
Outcomes
Primary Outcomes
Microcirculatory Flow Index (MFI) before and after blood transfusion.
Time Frame: One hour after the end of blood transfusion compared with before blood transfusion
Microcirculatory Flow Index detected in vivo by side-dark field imaging at sublingual microcirculation. It represents the quality of blood flow at microcirculatory level. This study wants to verify any of the considered different types of blood transfused can improve MFI.
Secondary Outcomes
- Perfused Vessel Density (PVD)(One hour after the end of blood transfusion compared with before blood transfusion)
- StO2 upslope(One hour after the end of blood transfusion compared with before blood transfusion)
- Arterial Blood Lactate(One hour after the end of blood transfusion compared with before blood transfusion)
- Arterial pH(One hour after the end of blood transfusion compared with before blood transfusion)
- SOFA score(One hour after the end of blood transfusion compared with before blood transfusion)