Comparison of short course cyclophosphamide followed by mycophenolate mofetil versus long course cyclophosphamide in the treatment of proliferative lupus nephritis.

Completed

• Conditions: Patients with SLE and biopsy proven proliferative lupus nephritis

• Registration Number: NL-OMON29290

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 124

Inclusion Criteria

1. Age 18 - 70 yrs;
2. SLE (presence of at least 4 ACR-criteria for SLE;
3. Proliferative lupus nephritis:
a. Biopsy proven lupus nephritis WHO class III or IV (according to Churg 1995).
and
b. Active sediment”. > 5 ery’s per HPF and/or celcylinders
and
c. Proteïnuria > 0.5 g/day;
4. Adequate anticonception;
5. Informed consent.

Exclusion Criteria

1. Active infection;
2. Pregnancy;
3. Known allergy for one of the study drugs;
4. Malignancy < 5 years prior to inclusion.

Study & Design

• Study Type: Interventional
• Study Design: Not specified