Influencing Factors of Cerebrovascular Disease and Cognition in Hemodialysis Patients

Recruiting

• Conditions: Cognitive Impairment; Cerebrovascular Disorders; Hemodialysis

• Registration Number: NCT04433455
• Lead Sponsor: Huashan Hospital

Brief Summary

In this observational study, the investigators evaluate the influencing factors of cerebrovascular disease and cognition in hemodialysis patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-05-19
• Study Start: 2020-06-01
• Study First Submitted QC: 2020-06-12
• Study First Posted: 2020-06-16
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-25
• Last Update Posted: 2024-02-28
• Primary Completion: 2025-05-31
• Study Completion: 2025-05-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. maintenance hemodialysis patients who are younger than 85 years old and older than 50 years old, regardless of gender
2. dialysis vintage is greater than 3 months;

Exclusion Criteria

1. Those with severe infection and anemia (Hb <60g / L);
2. Those with severe mental illness, metabolic diseases and immune system diseases;
3. Patients with abnormal liver function

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cerebrovascular disease	5 years	Magnetic resonance images will be used to determine the severity of white matter hyperintensity, using the Scheltens scale. Score 2 or more is abnormal.

Secondary Outcome Measures

Name	Time	Method
changes in cognitive function	5 years	The Mini-Mental State Examination (MMSE) will be used to assess the changes in cognitive function.The MMSE has a maximum score of 30 points. The scores are generally grouped as follows: 25-30 points: normal cognition 21-24 points: mild dementia 10-20 points: moderate dementia 9 points or lower: severe dementiaThe Mini-Mental State Examination (MMSE) will be used to assess the changes in cognitive function.The MMSE has a maximum score of 30 points. The scores are generally grouped as follows: 25-30 points: normal cognition 21-24 points: mild dementia 10-20 points: moderate dementia 9 points or lower: severe dementia

Trial Locations

Locations (1)

Huashan Hospital; 🇨🇳 Shanghai, Shanghai, China