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Clinical Trials/NCT06233630
NCT06233630
Recruiting
Phase 4

Erector Spinae Plane Block vs. iPACK Block With Adductor Canal Block for Total Knee Arthroplasty

Poznan University of Medical Sciences1 site in 1 country30 target enrollmentStarted: March 30, 2024Last updated:

Overview

Phase
Phase 4
Status
Recruiting
Sponsor
Poznan University of Medical Sciences
Enrollment
30
Locations
1
Primary Endpoint
Opioid consumption

Overview

Brief Summary

Effect of Erector Spinae Plane Block and iPACK block with Adductor Canal Block on pain management, and NLR and PLR following knee arthroplasty

Detailed Description

Knee arthroplasty is one of the most common orthopedic procedures, especially in elderly patients, due to the deformation of joints. Patients may complain of severe pain due to surgical trauma and prosthesis. Regional anesthesia methods may be performed to reduce the inflammatory response, opioid consumption, and opioid-related side effects.

In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, very few studies have evaluated the effect of various methods of anesthesia on the NLR.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
Triple (Participant, Care Provider, Outcomes Assessor)

Eligibility Criteria

Ages
18 Years to 100 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Patients with ASA classification I-III,
  • Aged 20-100 years,
  • scheduled for knee arthroplasty under spinal anaesthesia

Exclusion Criteria

  • Patients who have a history of bleeding diathesis,
  • Take anticoagulant therapy,
  • have a History of chronic pain before surgery,
  • have Multiple trauma,
  • cannot assess their pain (dementia),
  • have been operated on under general anaesthesia,
  • have an infection in the area
  • do not accept the procedure

Arms & Interventions

Placebo

Placebo Comparator

Only spinal anaesthesia - No peripheral nerve block

Intervention: Control Test - spinal anesthesia (Drug)

Erector Spinae Plane Block

Active Comparator

spinal anaesthesia and unilateral ultrasound guided erector spinae plane block - 20ml 0.2% ropivacaine

Intervention: Ropivacaine 0.2% Injectable Solution ESPB (Drug)

Infiltration Popliteal Artery and Capsule of the Knee and Adductor Canal Block

Active Comparator

spinal anaesthesia and ultrasound guided Infiltration of local anesthetic between the Popliteal Artery and Capsule of the Knee (iPACK) block - 20ml 0.2% ropivacaine

  • ultrasound guided Adductor Canal Block - 10ml 0.2% ropivacaine

Intervention: Ropivacaine 0.2% Injectable Solution iPACK+ACB (Drug)

Outcomes

Primary Outcomes

Opioid consumption

Time Frame: 48 hours

Total opiate consumption after surgery

Secondary Outcomes

  • Numerical Rating Scale [range 0:10](24 hours after surgery)
  • first need of opiate(48 hours)
  • NLR(24 hours postoperatively)
  • PLR(24 hours postoperatively)
  • Quadriceps muscle strength assessed using medical research council scale [range 0:5](24 hours after surgery)

Investigators

Sponsor
Poznan University of Medical Sciences
Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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