Longitudinal Evaluation of Vitrification of Human Oocytes
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 2
- 主要终点
- Oocytes survival after thaw
研究概览
简要总结
This study seeks to evaluate whether the vitrification technique, as compared to the more traditional slow-cooling technique, leads to higher rates of successful thawing, fertilization, implantation and delivery.
详细描述
Cryopreservation (freezing) of human gametes (unfertilized egg) provides a great potential to preserve or extend fertility in the face of disease and social circumstances (cancer diagnosis, delaying childbirth, single women, etc.). There are two methods for storage of oocytes (unfertilized eggs): slow freezing or vitrification (uses higher concentrations of cryoprotectant and faster cooling rates). Slow freezing is the standard method and has been successful for embryos since 1983 and more recently for oocytes. Recent reports indicate that vitrification may be more successful than slow freezing. The aim of this study is to examine the rate at which frozen eggs survive freezing and thawing, the rate at which the frozen/thawed eggs fertilize with sperm and the pregnancy outcomes of oocyte (egg) vitrification cycles to determine whether the outcomes are similar or better than standard oocyte (egg) cryopreservation (freezing) cycles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age between 21 and 50 years, at the time of informed consent.
- •Subjects must agree to undergo intracytoplasmic sperm injection (ICSI)
排除标准
- •Presence of any medical condition that contraindicates ovarian stimulation, in vitro fertilization or pregnancy.
结局指标
主要结局
Oocytes survival after thaw
时间窗: 1 month
Whether each oocyte survives the thawing process
次要结局
- Fertilization(1 month)
- Implantation(1 month)