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Clinical Trials/TCTR20200916008
TCTR20200916008
Recruiting
Phase 4

Effect of Continuous Positive Airway Pressure on Time to Resolution of Dengue-associated Pleural Effusion

Mahidol Oxford Research Unit0 sites74 target enrollmentSeptember 16, 2020
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ConditionsDengue is a global problem and is common in more than 120 countries&#44mainly in Asia and South America. Each year millions of people are infected and up to 20&#44000 die.Dengue hemorrhagic fever&#44pleural effusion&#44Continuous Positive Airway Pressure

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Dengue is a global problem and is common in more than 120 countries&#44
Sponsor
Mahidol Oxford Research Unit
Enrollment
74
Status
Recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
September 16, 2020
End Date
June 1, 2021
Last Updated
last year
Study Type
Interventional
Sex
All

Investigators

Sponsor
Mahidol Oxford Research Unit

Eligibility Criteria

Inclusion Criteria

  • •1\.Age \> 18 years;
  • •2\.Dengue infection confirmed by either antigen detection e.g. PCR for RNA, NS1Ag or antibodies detection e.g. IgM ELISA, paired IgG ELISA methods;
  • •3\.Newly detected pleural effusion of at least 2 centimeters detected by chest ultrasound at posterior part of right diaphragm in upright position in 24 to 48 hours after fever has disappeared.

Exclusion Criteria

  • •1\. An underlying disorder causative of pleural effusion e.g. tuberculous effusion, malignancy effusion, cirrhosis, heart failure, etc.
  • •2\.Contraindication to CPAP, e.g., coma, shock or known intolerance for NIV/CPAP
  • •3\.Pregnancy
  • •4\.No informed consent
  • •5\. Cannot communicate with Thai or English language

Outcomes

Primary Outcomes

Not specified

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