Effect of Continuous Positive Airway Pressure on Time to Resolution of Dengue-associated Pleural Effusio
Phase 4
Recruiting
- Conditions
- Dengue is a global problem and is common in more than 120 countries,mainly in Asia and South America. Each year millions of people are infected and up to 20ꯠ die.Dengue hemorrhagic fever,pleural effusion,Continuous Positive Airway Pressure
- Registration Number
- TCTR20200916008
- Lead Sponsor
- Mahidol Oxford Research Unit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 74
Inclusion Criteria
1.Age > 18 years;
2.Dengue infection confirmed by either antigen detection e.g. PCR for RNA, NS1Ag or antibodies detection e.g. IgM ELISA, paired IgG ELISA methods;
3.Newly detected pleural effusion of at least 2 centimeters detected by chest ultrasound at posterior part of right diaphragm in upright position in 24 to 48 hours after fever has disappeared.
Exclusion Criteria
1. An underlying disorder causative of pleural effusion e.g. tuberculous effusion, malignancy effusion, cirrhosis, heart failure, etc.
2.Contraindication to CPAP, e.g., coma, shock or known intolerance for NIV/CPAP
3.Pregnancy
4.No informed consent
5. Cannot communicate with Thai or English language
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pleural effusion resolution time Time since newly detected pleural effusion till resolution of pleural effusion chest ultrasound
- Secondary Outcome Measures
Name Time Method Dyspnea score Time since newly detected pleural effusion till resolution of pleural effusion Modified Borg Score