The Combination of Tirzepatide and Resistance EXercise (T-REX) for the Management of Body Compositio

Phase 3

Not yet recruiting

• Conditions: Obesity; Overweight; Metabolic and Endocrine - Normal metabolism and endocrine development and function; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12623001236684
• Lead Sponsor: The University of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-11-30
• Last Update Posted: 12 December 2023

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Men and women aged 50-70 years with body mass index (BMI) greater than or equal to 30 kg/m², or greater than or equal to 27 kg/m² with at least one weight-related comorbidity (e.g. hypertension, dyslipidaemia or obstructive sleep apnoea)

Exclusion Criteria

Known pregnancy, cardiovascular disease, diabetes, any history of pancreatitis; any history of multiple endocrine neoplasia (MEN) type 2 or medullary thyroid carcinoma; previous or planned bariatric surgery; any prior use of incretin-based therapies; use of non-incretin based anti-obesity or CV medications (e.g. statins, BP drugs) within 3 months of enrolment; and any other clinically significant illnesses (e.g. cancer, severe respiratory disease). Total cholesterol greater than 7.0 mmol/L, LDL greater than 4.0 mmol/L, eGFR less than 45 mL/min, HbA1c greater than 7.0% and/or evidence of significant liver disease. BP greater than 160/100 mmHg during the clinic visit.

Study & Design

• Study Type: Interventional
• Study Design: Not specified