Effects of e-Cigarettes on Perceptions and Behavior - Substudy 2

Not Applicable

Completed

• Conditions: Electronic Cigarette Use; Cigarette Use, Electronic; Cigarette Smoking; E-Cig Use
• Interventions: Other: E-cigarette e-liquid self-administration

• Registration Number: NCT05958966
• Lead Sponsor: University of Southern California

Brief Summary

This project will assess the ways in which e-cigarette product diversity impacts the user experience to inform potential regulations by identifying product characteristics that may: (1) put young adults at risk for tobacco product use; and (2) facilitate adult smokers switching to e-cigarettes. There are three primary objectives to the study: (1) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect product appeal across young adult e-cigarette users and middle-age/older adult smokers; (2) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect abuse liability in young adult e-cigarette users and the ability to resist smoking in adult smokers; (3) Determine the affect of product characteristics on e-cigarette nicotine delivery profile. For this substudy, adult smokers (N=200) will attend two laboratory session in which they will self-administer e-cigarette products varied according to within-subject e-cigarette factors (e.g., flavor, nicotine formulation) and smoke their own cigarettes.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-04-01
• Primary Completion: 2023-05-01
• Study Completion: 2023-05-01
• Status Verified: 2023-07
• Study First Submitted: 2023-07-07
• Study First Submitted QC: 2023-07-14
• Last Update Submitted: 2023-07-14
• Study First Posted: 2023-07-25
• Last Update Posted: 2023-07-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 73

Inclusion Criteria

• Regular use of cigarettes containing nicotine.

Exclusion Criteria

• Pregnant or planning to become pregnant.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
E-cigarette e-liquid 3	E-cigarette e-liquid self-administration	Participants will self-administer an e-cigarette e-liquid.
E-cigarette e-liquid 2	E-cigarette e-liquid self-administration	Participants will self-administer an e-cigarette e-liquid.
E-cigarette e-liquid 1	E-cigarette e-liquid self-administration	Participants will self-administer an e-cigarette e-liquid.
E-cigarette e-liquid 4	E-cigarette e-liquid self-administration	Participants will self-administer an e-cigarette e-liquid.

Primary Outcome Measures

Name	Time	Method
Subjective Appeal Rating Questionnaire	1 hour	This self-report measure of product appeal will be completed following e-cigarette self-administration. Scores can range from 0 to 100 for the appeal rating, with lower scores representing lower levels of appeal and higher scores representing higher levels of appeal.
Smoking Delay Task	1 hour	Minutes delayed before purchasing time to smoke own cigarettes. Scores can range from 0mins to 50mins for the smoking delay task, with lower scores representing fewer minutes delayed from smoking and higher scores representing longer minutes delayed from smoking.
Sensory Attributes Rating Questionnaire	1 hour	This self-report measure of product sensory attributes will be completed following e-cigarette self-administration. Scores can range from 0 to 100 for the sensory attribute rating, with lower scores representing lower levels of liking the sensory attribute and higher scores representing greater liking of the sensory attribute.

Trial Locations

Locations (1)

University of Southern California; 🇺🇸 Los Angeles, California, United States