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Clinical Trials/NCT01647243
NCT01647243
Unknown
Not Applicable

Effect of Preoperative Strength Training on Postoperative Quadriceps Strength and Ability of Function in Patients With Total Knee Arthroplasty in Fast Track Regi

University of Aarhus1 site in 1 country70 target enrollmentJanuary 2012

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Osteoarthritis, Knee
Sponsor
University of Aarhus
Enrollment
70
Locations
1
Primary Endpoint
Primary outcome: Sit-to-stand test
Last Updated
13 years ago

Overview

Brief Summary

The purpose of this study is to investigate if preoperative strength training will result in faster recovery and higher level of function six weeks after total knee arthroplasty (TKA).

Detailed Description

Reduced strength of the quadriceps muscle is a common clinical finding in patients with Knee Osteoarthritis and this seems to play a central role in the development of the disease. The strength of the quadriceps muscle have been shown to be reduced by 20-40% as compared to age-matched healthy controls and this decrease in muscle strength have been closely associated with a reduced level of function and increase of pain. Furthermore, it has been demonstrated that the preoperative strength of the quadriceps muscle in patients undergoing TKA, is associated with the level of function one year after surgery. Compared to the level before the operation, an additional operation-induced reduction of the strength of the quadriceps muscle up to 60% as has been demonstrated. Presumably, an optimizing of the strength of the quadriceps muscle could counteract the impact of the expected postoperative loss of muscle strength to such an extent that the loss will be of less clinical significance. It is hypothesized that an optimizing of the strength of the quadriceps muscle may have a favorable effect on the postoperative rehabilitation program and shorten the period of convalescence.

Registry
clinicaltrials.gov
Start Date
January 2012
End Date
December 2013
Last Updated
13 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Planned TKA at the Aarhus University Hospital or Region Hospital Silkeborg,
  • Living in Aarhus Municipality,
  • Primary knee osteoarthritis or secondary osteoarthritis after meniscectomy or ligament injury

Exclusion Criteria

  • Unstable blood pressure,
  • Neuromuscular or neurodegenerative disease,
  • Comprehension or dementia problems

Outcomes

Primary Outcomes

Primary outcome: Sit-to-stand test

Time Frame: Change from Baseline 6 weeks preoperative in Sit-to-Stand at 6 weeks postoperative

Ability of function test

Secondary Outcomes

  • Isokinetic: Quadriceps 60 gr./sek(6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • Isokinetic: Hamstrings 60 gr./sek(6 weeks and 1 week before the operation, 1 week, 6 weeks 12 weeks and 1 year after the operation)
  • Isometric: Quadriceps (70 gr. flexion)(6 weeks and 1 week before the operation and 11 week, 6 weeks, 12 weeks and 1 year after the operation)
  • Isometric: Hamstrings (20 gr. flexion)(6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • Rate of force development (flexion and extension)(6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • Timed Up and Go(6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • 10 meter walk test(6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • 6 minute walk test(6 weeks and 1 week before operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • Knee injury and Osteoarthritis Outcome Score (KOOS)(6 weeks and 1 week before operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • Oxford Knee Score (OKS)(6 weeks before the operation and 6 weeks after)
  • EuroQol-5 dimensions (EQ-5D)(6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • Short-Form Health Survey (SF 12)(6 weeks before the operation and 1 year after)
  • Background data questionnaire(6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • Range of motion of the knee(6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)
  • Body mass index(6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation)

Study Sites (1)

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