Preoperative Strength Training in Patients With Total Knee Arthroplasty

Not Applicable

• Conditions: Osteoarthritis, Knee
• Interventions: Other: Preoperative strength training

• Registration Number: NCT01647243
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of this study is to investigate if preoperative strength training will result in faster recovery and higher level of function six weeks after total knee arthroplasty (TKA).

Detailed Description

Reduced strength of the quadriceps muscle is a common clinical finding in patients with Knee Osteoarthritis and this seems to play a central role in the development of the disease. The strength of the quadriceps muscle have been shown to be reduced by 20-40% as compared to age-matched healthy controls and this decrease in muscle strength have been closely associated with a reduced level of function and increase of pain. Furthermore, it has been demonstrated that the preoperative strength of the quadriceps muscle in patients undergoing TKA, is associated with the level of function one year after surgery. Compared to the level before the operation, an additional operation-induced reduction of the strength of the quadriceps muscle up to 60% as has been demonstrated. Presumably, an optimizing of the strength of the quadriceps muscle could counteract the impact of the expected postoperative loss of muscle strength to such an extent that the loss will be of less clinical significance. It is hypothesized that an optimizing of the strength of the quadriceps muscle may have a favorable effect on the postoperative rehabilitation program and shorten the period of convalescence.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-01
• Status Verified: 2012-07
• Study First Submitted: 2012-07-13
• Study First Submitted QC: 2012-07-20
• Last Update Submitted: 2012-07-20
• Study First Posted: 2012-07-23
• Last Update Posted: 2012-07-23
• Primary Completion: 2013-10
• Study Completion: 2013-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Planned TKA at the Aarhus University Hospital or Region Hospital Silkeborg,
• Living in Aarhus Municipality,
• Primary knee osteoarthritis or secondary osteoarthritis after meniscectomy or ligament injury

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Exclusion Criteria

• Unstable blood pressure,
• Neuromuscular or neurodegenerative disease,
• Comprehension or dementia problems

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Preoperative strength training	Preoperative strength training	Progressive strength training on group basis four weeks before the operation and progressive strength training on group basis four weeks after the operation

Primary Outcome Measures

Name	Time	Method
Primary outcome: Sit-to-stand test	Change from Baseline 6 weeks preoperative in Sit-to-Stand at 6 weeks postoperative	Ability of function test

Secondary Outcome Measures

Name	Time	Method
Isokinetic: Quadriceps 60 gr./sek	6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Muscle strength test in dynamometer
Isokinetic: Hamstrings 60 gr./sek	6 weeks and 1 week before the operation, 1 week, 6 weeks 12 weeks and 1 year after the operation	Muscle strength test in dynamometer
Isometric: Quadriceps (70 gr. flexion)	6 weeks and 1 week before the operation and 11 week, 6 weeks, 12 weeks and 1 year after the operation	Muscle strength test in dynamometer
Isometric: Hamstrings (20 gr. flexion)	6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Muscle strength test in dynamometer
Rate of force development (flexion and extension)	6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Muscle test in dynamometer
Timed Up and Go	6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Ability of function test
10 meter walk test	6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Ability of function test
6 minute walk test	6 weeks and 1 week before operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Ability of function test
Knee injury and Osteoarthritis Outcome Score (KOOS)	6 weeks and 1 week before operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Disease-specific questionnaire
Oxford Knee Score (OKS)	6 weeks before the operation and 6 weeks after	Disease-specific questionnaire
EuroQol-5 dimensions (EQ-5D)	6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Generic questionnaire for self-rated health
Short-Form Health Survey (SF 12)	6 weeks before the operation and 1 year after	Generic questionnaire for self-rated health
Background data questionnaire	6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Questionnaire about pain, medicine use, alcohol intake, smoking, education, job
Range of motion of the knee	6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Extension of the knee Flexion of the knee
Body mass index	6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation	Weight/height2

Trial Locations

Locations (1)

Aarhus University hospital; 🇩🇰 Aarhus, Denmark