Studies on the antihypertensive effect and uric acid metabolism by the combination therapy of ARB and diuretics in the CKD patients with hypertension - Comparison between daily and alternate-daily medication of diuretics
Not Applicable
Recruiting
- Conditions
- The CKD patients with hypertension
- Registration Number
- JPRN-UMIN000010170
- Lead Sponsor
- Department of Internal Medcine, Teikyo University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
1) The patient with contraindication of irbesartan medication 1. Patients with a history of hypersensitivity to any component of this drug 2. Patients during pregnancy and with pregnant possibility 2) The patient with contraindication of the trichrolmethiazide medication 1. Patients with anuria 2. Patients with acute renal failure 3. Patients with hyponatremia, and hypokalemia 4. Patients with a history of hypersensitivity to thiazides or analogues 3) Patients who are judged ineligible for any other reasons by the investigator
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Change of blood pressure (office blood pressure, home blood pressure) 2. Changes of serum uric acid level
- Secondary Outcome Measures
Name Time Method 1. Changes in renal function (serum creatinine, eGFR, serum cystatin C et al.) 2. Changes in urinary examinations (urine protein et al.) 3. Changes of metabolic biomarkers (lipids, glucose and electrolytes) 4. Changes of heart rate