Migraine and Endothelial Dysfunction – a brain magnetic resonance (MR) imaging case-control study

Recruiting

Conditions: G43.1
G43.0
Migraine with aura [classical migraine]
Migraine without aura [common migraine]

Registration Number: DRKS00030198

Lead Sponsor: Charité Campus Charité Mitte

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 300

Inclusion Criteria

Patients:
- episodic migraine with or without aura according to ICHD-3 criteria
- existing health insurance

Healthy control subjects:
Individuals without a diagnosis of migraine according to ICHD3 criteria who meet the exclusion criteria below. Control subjects will be recruited matched for age and gender of patients.

Exclusion Criteria

- other headache disorder according to ICHD-3 criteria except episodic tension headache (<15 days/month)
- other neurological disorder (eg, multiple sclerosis, brain tumour, recent severe traumatic brain injury, recent brain surgery)
- severe inflammatory disease (infectious, rheumatic)
- Raynaud's syndrome
- cardiovascular disease (stroke, CAD, myocardial infarction, PAOD, severe valvular disease, decompensated heart failure)
-Cardiovascular risk factors (diabetes mellitus, arterial hypertension difficult to control with medication (>2 antihypertensive drugs), body mass index < 18 / > 30 kg/m2
- pregnancy
- severe psychiatric illness, addicition to alcohol or drugs
- other medical condition that, in the opinion of the study physician after evaluation of benefit and risk, is not compatible with study participation.
- drugs: statins, anticoagulants, triptan therapy (<24h).
- contraindication for MRI

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint is the level of endothelial microvesicles compared between migraine patients with different severities of WMH. Microvesicles will be determined by FACS analysis from peripheral venous blood obtained on the day of the MRI scan (one single study visit). The primary hypothesis is that endothelial biomarkers are associated with the presence of and severity of WMH in migraine patients.

Secondary Outcome Measures