Microbiome and Colorectal Cancer Recurrence

Completed

• Conditions: Colorectal Cancer Recurrent

• Registration Number: NCT07057076
• Lead Sponsor: Hospital del Mar

Brief Summary

Anastomotic leak is associated with higher rates of tumor recurrence after colorectal cancer surgery. However, the mechanisms responsible remain unknown. The aim of this study is to identify associations between the peritoneal microbiome and recurrence in colorectal cancer patients with postoperative anastomotic leak. This is a single-center retrospective study of patients undergoing colorectal cancer surgery complicated with anastomotic leak between 2004 and 2012. Samples of peritoneal fluid were collected either through percutaneous drainage or reoperation, and microbiome was analyzed using whole genome shotgun. Oncological outcomes are registered. Associations between peritoneal microbiome and tumor recurrence are investigated.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-01-01
• Primary Completion: 2024-06-01
• Study Completion: 2024-06-01
• Status Verified: 2025-06
• Study First Submitted: 2025-06-29
• Study First Submitted QC: 2025-06-29
• Last Update Submitted: 2025-06-29
• Study First Posted: 2025-07-09
• Last Update Posted: 2025-07-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• Colorectal cancer patients operated on for cure and complicated with anastomotic leak.

Exclusion Criteria

• Non-curative resection.
• Urgent surgery.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recurrence	5 years	Colorectal cancer recurrence after surgery