Relationship between activity in heme oxygenase-1 (HO-1) and risk factors for cardiovascular diseases in patients with obstructive sleep apnea (OSA)

Not Applicable

• Conditions: Obstructive sleep apnea syndrome

• Registration Number: JPRN-UMIN000006924
• Lead Sponsor: Kyoto University Graduate School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-12-21
• Study Completion: 2014-08-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Not provided

Exclusion Criteria

*Smoker *Patients with smoking history within 6 months *Patients with chronic pulmonary disease (Bronchial asthma, chronic obstructive pulmonary disease (COPD), interstitial pneumonia, etc) *Patients under treatment for acute infection disease or malignant disease *Patients who cannot take a meal tolerance test

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The correlation between changes in fraction of carbon monoxide (CO) during sleep and degrees of vascular endothelial dysfunction, intima media thickness, glucose intolerance, heart function, and proBNP

Secondary Outcome Measures

Name	Time	Method
Association between severity of obstructive sleep apnea (OSA) and fraction of CO, vascular endothelial dysfunction, glucose intolerance, postprandial lipid metabolism, heart function, proBNP, and serum and urinary biomarkers Changes in fraction of CO, vascular endothelial dysfunction, glucose intolerance, postprandial lipid metabolism, heart function, proBNP, and serum and urinary biomarkers in patients with OSA before and after CPAP treatment