Association of sodium channel Single Nucleotide Polymorphism (SNP) with valproate response among bipolar disorder patients in a tertiary care hospital A Longitudinal study.

This study is a longitudinal pharmacogenomic study aimed at evaluating the association between sodium channel gene single nucleotide polymorphisms (SNPs) and therapeutic response to valproate in patients with bipolar disorder from a South Indian population. Adult patients (18–60 years) diagnosed with bipolar disorder and prescribed sodium valproate will be enrolled and followed for 6 weeks. Treatment response will be assessed using Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS), and patients will be classified as responders or non-responders. Genotyping of SCN1A SNP (rs2298771) will be performed using PCR–RFLP technique. Secondary outcomes include medication adherence, safety profile, and proportion of non-responders. A total sample size of 96 participants will be included. Data will be analyzed using appropriate statistical tests to determine genetic association, with the aim of supporting personalized valproate therapy in bipolar disorder.