Optical Biometry and Spherical Aberration in Ametropic and Emmetropic Eyes

Completed

• Conditions: Refractive Errors; Axial Length, Eye; Corneal Wavefront Aberration

• Registration Number: NCT01663597
• Lead Sponsor: Medical University of Vienna

Brief Summary

Aberrations play a significant role in the visual process and can be divided in lower-order and higher-order aberrations. The former can be measured using the commercially available IOL Master (Carl Zeiss Meditec AG, Germany) and have profound influence on visual acuity. Higher-order aberrations do not significantly influence visual acuity but affect the quality of vision and can cause halos, double vision, and night vision disturbances.

Background Cataract surgery has become a routine procedure in the developed countries. During this surgery, a foldable intraocular lens is usually inserted into the capsular bag. However, these lenses do not account for individual optical biometry data or aberrations. Therefore, it is important to provide data for ametropic and emmetropic eyes as this information might improve future intraocular lens design and lead to individually adapted lenses for yielding optimal visual acuity and quality results.

The aim of the present study is to clarify the correlation between refractive errors/axial eye length and spherical aberrations of the cornea.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-08
• Study First Submitted: 2012-08-09
• Study First Submitted QC: 2012-08-10
• Study First Posted: 2012-08-13
• Primary Completion: 2013-05
• Study Completion: 2013-05
• Status Verified: 2013-08
• Last Update Submitted: 2013-08-28
• Last Update Posted: 2013-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• men and women aged between 40 and 60 years
• normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant
• normal ophthalmic findings unless the investigator considers an abnormality to be clinically irrelevant

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Exclusion Criteria

• presence of any corneal or retinal disease
• Dry eye syndrome
• high astigmatism (>1 diopter)
• history of refractive surgery
• abuse of alcoholic beverages
• participation in a clinical trial in the 3 weeks preceding the study
• symptoms of a clinically relevant illness in the 3 weeks before the study day
• pregnancy

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Axial eye length	1 day

Secondary Outcome Measures

Name	Time	Method
Refractive error	1 day
Corneal radius	1 day
Pupil diameter	1 day
Anterior chamber depth	1 day
Anterior corneal topography	1 day
Corneal thickness map	1 day

Trial Locations

Locations (1)

Department of Clinical Pharmacology, Medical University of Vienna; 🇦🇹 Vienna, Austria