Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO-study) - ENDURO-study

niversitair Medisch Centrum Utrecht0 个研究点目标入组 96 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•- Adult patients with symptomatic malignant gastric outlet obstruction,
•presenting with nausea, vomiting and/or inability to eat
•- Gastric Outlet Obstruction Scoring System Score of 0 (no oral intake) or 1
•(liquids only)
•- Obstruction due to irresectable or metastatic malignancy without curative
•treatment options
•- Radiologically or endoscopically confirmed gastric outlet obstruction
•- Location of obstruction extending from the distal 1/3 of the stomach (antrum)
•to the distal duodenum (third part)
•- Both treatments (SGJ and EUS-GE) are technically and clinically feasible
•- Written informed consent

•- Radiological or clinical suspicion of other strictures or obstructions along
•the gastrointestinal tract (distal of Treitz), with small intestine intestinal
•dilation/ileus. Note: patients with diffuse dilatation of the intestines should
•not be excluded;
•- Cancer extending into the body of the stomach or around the ligament of
•- Duodenal tube feeding is not tolerated by the patient, despite adequate
•position of the tube;
•- Altered anatomy after previous gastric, periampullary or duodenal surgery;
•- Previous SGJ as palliative treatment for the same condition;
•- Inability to undergo surgery or upper endoscopy due to severe comorbidities;
•- WHO performance score of 4 (in bed 100% of time);
•- Uncorrectable coagulopathy, defined by INR>1.5 or platelets < 50 x 10^9/L;

发起方

niversitair Medisch Centrum Utrecht