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Clinical Trials/NCT05984849
NCT05984849
Recruiting
Not Applicable

A Pilot Randomized Controlled Study to Examine Feasibility and Preliminary Effectiveness of a Game-based Intervention in Promoting HPV Vaccination Among Vulnerable Youth to Prevent Cancers

Michigan State University1 site in 1 country180 target enrollmentSeptember 1, 2025

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Not specified
Sponsor
Michigan State University
Enrollment
180
Locations
1
Primary Endpoint
Percentage of eligible individuals agreeing to participate
Status
Recruiting
Last Updated
7 months ago

Overview

Brief Summary

This proposed study aims to conduct timely research that promotes vaccine confidence and vaccination of one strongly recommended vaccine with suboptimal uptake rates: Human papillomavirus (HPV) in vulnerable and underserved youth aged 11-14.

Detailed Description

The study objectives are: Objective 1: Assess feasibility (participation rate, retention, involvement, satisfaction) of one game-based interventions targeting HPV vaccination. Objective 2: Conduct a pilot RCT with three conditions (Arm 1: HPV game-based intervention; Arm 2: usual care). The investigators will explore patterns of pre- to post-intervention change in theoretical mediators and vaccine intent, and explore levels of vaccine intent and uptake in 90 parent-child dyads of unvaccinated youth aged 11-14.

Registry
clinicaltrials.gov
Start Date
September 1, 2025
End Date
August 1, 2027
Last Updated
7 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Angela Chia-Chen Chen

Professor

Michigan State University

Eligibility Criteria

Inclusion Criteria

  • Child sample: (1) 11-14 years old, (2) speaks and reads English, (3) has never received any doses of the HPV vaccine, (4) is not currently enrolled in another project that involves HPV-related education, and (5) agrees and provides assent to participate in research activities.
  • Parent sample: (1) parent or legal guardian of the participating child, (2) speak and read English, (3) own a smartphone, (4) agree to receive email and text messages, (5) is not currently enrolled in another project that involves HPV-related education, and (6) agree and provide consent to participate in research activities.

Exclusion Criteria

  • Individuals who do not meet inclusion criteria or refuse to provide consent/assent.

Outcomes

Primary Outcomes

Percentage of eligible individuals agreeing to participate

Time Frame: T0 (occurs after consenting and before assigning to different study conditions)

Assessed by the % of eligible individuals agreeing to participate

Proportion of participants who are retained through follow-up

Time Frame: T2 (occurs two months after completion of the intervention)

Assessed by the % of participants who are retained through follow-up

Percentage of participants who complete the intervention and assessments

Time Frame: T2 (occurs two months after completion of the intervention)

Assessed by the % of participants who complete the intervention and assessments

Intention to vaccinate the children against HPV

Time Frame: T0 (occurs after consenting and before assigning to different study conditions); T1 (occurs immediately post intervention);T2 (occurs two months after completion of the intervention)

Assessed by a Likert scale question: How likely will you (parent) vaccinate your child against HPV? Responses: (0) no; (1) maybe; (2) yes

Participant satisfaction with the project

Time Frame: T2 (occurs two months after completion of the intervention)

Assessed by two Likert scale questions: (1) are you satisfied with the program? (2) Will you recommend this program to others? Responses: from (1) very dissatisfied/definitely not to (5) very satisfied/definitely yes)

Secondary Outcomes

  • Children receives the first dose of HPV vaccine(T2 (occurs two months after completion of the intervention))

Study Sites (1)

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