NCT02632578
Completed
Not Applicable
A Comparison of Immune Responses to the Licensed Trivalent Inactivated Influenza Vaccine in HIV-positive and HIV-negative Subjects
ConditionsInfluenza, Human
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Influenza, Human
- Sponsor
- University of Melbourne
- Enrollment
- 57
- Primary Endpoint
- Anti-influenza antibody responses in plasma with Fc-mediated functions
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The aims of this study are:
- to investigate if HIV infection alters the antibody responses to influenza and
- to assess the ability of licensed influenza vaccine to induce functional non-neutralising antibodies in HIV-infected and HIV-uninfected subjects.
Investigators
Prof Stephen Kent
Professor
University of Melbourne
Eligibility Criteria
Inclusion Criteria
- •HIV-1 positive by licensed diagnostic test (for HIV-positive group only)
- •Planning to receive the seasonal influenza vaccine outside the study
- •Provision of written informed consent
Exclusion Criteria
- •Previous allergy to influenza vaccination
- •Pregnancy or planning to become pregnant
- •Unwilling or unable to provide blood samples
Outcomes
Primary Outcomes
Anti-influenza antibody responses in plasma with Fc-mediated functions
Time Frame: Four weeks after influenza vaccination
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