Influenza Vaccine in HIV Study

Completed

• Conditions: Influenza, Human

• Registration Number: NCT02632578
• Lead Sponsor: University of Melbourne

Brief Summary

The aims of this study are:

1. to investigate if HIV infection alters the antibody responses to influenza and

2. to assess the ability of licensed influenza vaccine to induce functional non-neutralising antibodies in HIV-infected and HIV-uninfected subjects.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-02
• Primary Completion: 2015-06
• Status Verified: 2015-12
• Study Completion: 2015-12
• Study First Submitted: 2015-12-14
• Study First Submitted QC: 2015-12-15
• Last Update Submitted: 2015-12-15
• Study First Posted: 2015-12-16
• Last Update Posted: 2015-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 57

Inclusion Criteria

• HIV-1 positive by licensed diagnostic test (for HIV-positive group only)
• Planning to receive the seasonal influenza vaccine outside the study
• Provision of written informed consent

Exclusion Criteria

• Previous allergy to influenza vaccination
• Pregnancy or planning to become pregnant
• Unwilling or unable to provide blood samples

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Anti-influenza antibody responses in plasma with Fc-mediated functions	Four weeks after influenza vaccination