Ambulatory Anesthesia and Light Therapy

Not Applicable

• Conditions: Anesthesia; Colonoscopy
• Interventions: Other: light therapy (1500 lux); Other: standard light (100 LUX)

• Registration Number: NCT00813345
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

We previously evidenced in both animal models and patients that a short duration ambulatory anesthesia impacts the circadian rest-activity biological rhythm, at least during the first 3 days. The light is the main, natural synchronisateur, of the biological cerebral clock, and is used as therapeutics in chronic disturbances of the circadian rest activity rhythm and of the sleep (Alzheimer disease for example). We would like to test for a simple and safe strategy to prevent such a long-lasting effect of anesthesia on biological clock:the increase of the light intensity at a still physiological level during the initial phase of recovery from anesthesia by using a particular artificial light of color spectrum similar to natural sun daylight.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-12-22
• Study First Submitted QC: 2008-12-22
• Study First Posted: 2008-12-23
• Study Start: 2009-01
• Status Verified: 2009-04
• Last Update Submitted: 2009-04-24
• Last Update Posted: 2009-04-27
• Primary Completion: 2009-12
• Study Completion: 2010-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 360

Inclusion Criteria

• ASA I & II
• ambulatory anesthesia for colonoscopy on Monday or Tuesday
• social security

Exclusion Criteria

• treatment for cancer
• hypnotics, beta-bloquers
• pregnancy
• legal supervision
• trans 5 meridian travel in the last two months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
A - Light therapy	light therapy (1500 lux)	Light therapy (1500 lux)
B - identical control lamp	standard light (100 LUX)	identical control lamp

Primary Outcome Measures

Name	Time	Method
Modification of on parametric analysis of circadian rhythm of rest-activity post anesthesia as compared to reference period (within factor) ; between factor : light intensity group	Within the first 5 days after anesthesia

Secondary Outcome Measures

Name	Time	Method
Influence of gene period 3 phenotype on the effect of anesthesia	Blood sample taken the day of the anesthesia

Trial Locations

Locations (6)

Service d'Anesthésie et Réanimation, Hôpital d'Instruction des Armées Legouest; 🇫🇷 Metz, France

Service d'Anestésie et Réanimation - Hôpital Beaujon; 🇫🇷 Clichy, France

Centre Ambulatoire-Clinique Saint-Odile; 🇫🇷 Strasbourg, France

Centre Ambulatoire des Diaconesses; 🇫🇷 Strasbourg, France

Service d'Anesthésie et Réanimation - Hôpital de Hautepierre; 🇫🇷 Strasbourg, France

Service d'Anesthésie et Réanimation - Hôpital Pasteur; 🇫🇷 Colmar, France