Craving Assessment in Patients With Alcohol Use Disorder Using Virtual Reality Exposure
- Conditions
- Alcohol Use Disorder
- Registration Number
- NCT05861843
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 61
Inclusion Criteria:<br><br> - age: 18-65 years<br><br> - diagnosis of alcohol dependence according to ICD-10 (F10.2)<br><br> - completed in-patient withdrawal treatment during the last 3 months<br><br> - history of alcohol craving, confirmed via craving questionnaires<br><br> - able to provide written informed consent<br><br>Exclusion Criteria:<br><br> - substance dependence other than alcohol and nicotine<br><br> - current alcohol intoxication (randomly tested via measurement of breath alcohol<br> concentration)<br><br> - unable to understand the study information, consent form or principles of the study<br><br> - abstinence for less than 7 days or on-going consumption of alcohol<br><br> - severe neuropsychiatric disorder, e.g. schizophrenia spectrum disorders, bipolar<br> affective disorder or substantial cognitive impairment<br><br> - serious illnesses influencing brain-/heart-function with influence on physiological<br> study parameters.<br><br> - acute suicidality (or acute endangerment of others)<br><br> - concurrent pharmacological treatment targeting AUD (i.e. benzodiazepines) or craving<br> (i.e. acamprosate, disulfiram, naltrexone, nalmefene) and further medication<br> significantly influencing heart frequency.
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change in subjective craving levels elicited by alcohol-associated cues;change in psychophysiological craving levels (heart rate) elicited by alcohol-associated cues;change in psychophysiological craving levels (heart rate variability) elicited by alcohol-associated cues;change in psychophysiological craving levels (electrodermal activity) elicited by alcohol-associated cues;change in psychophysiological craving levels elicited by alcohol-associated cues
- Secondary Outcome Measures
Name Time Method context-related change in craving levels;development of subjective craving levels post-exposure