Minimal Stimulation or Clomiphene Citrate in Treatment of Polycystic Ovary Syndrome
Not Applicable
Completed
- Conditions
- Polycystic Ovary Syndrome
- Interventions
- Registration Number
- NCT01157312
- Lead Sponsor
- Mansoura University
- Brief Summary
The purpose of this study is to compare and determine the the efficacy of minimal stimulation and clomiphene citrate(CC) as the first-line treatment in infertile women with Polycystic Ovary Syndrome(PCOS).
- Detailed Description
All patients received 100 mg CC (Clomid®; Global Napi Pharmaceuticals, Cairo, Egypt) for 5 days starting from day 3 of spontaneous or induced menstruation. In group A (minimal stimulation), 2 vials of highly purified uFSH , 150 IU (Fostimon; IBSA, Lugano, Switzerland, 75 IU/vial) were given IM on cycle day 9. A total of 3 cycles was offered to each group.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 113
Inclusion Criteria
- PCOS
- No other infertility factors
- No previous use of ovarian stimulation drugs
Exclusion Criteria
- Congenital adrenal hyperplasia
- Cushing syndrome
- Androgen secreting tumors
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description minimal stimulation protocol clomiphene citrate +highly purified uFSH 5 days of CC (100mg/day) from day 3 followed by 150 IU of highly purified uFSH on cycle day 9 for three treatment cycles clomiphene citrate(CC) clomiphene citrate 5 days of CC (100mg/day) from cycle day 3 for three treatment cycles.
- Primary Outcome Measures
Name Time Method clinical pregnancy rate per cycle
- Secondary Outcome Measures
Name Time Method endometrial thickness at the time of hCG administration
Trial Locations
- Locations (1)
Mansoura University Hospitals,OB/GYN department
🇪🇬Mansoura, Dakahlia Governorate, Egypt