Clinical Comparison of Topical Application of Curcumin Gel Versus Gelatin Sponge in Pain Management and Wound Healing After Free Gingival Graft Harvesting: a Randomized Controlled Clinical Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- post-operative pain
研究概览
简要总结
The aim of this study is to compare the effect of using 2% curcumin gel versus gelatin sponge when applied to palatal donor site in pain management and wound healing after free gingival graft harvesting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Systematically healthy patient (American Society of Anesthesiology class I and II).
- •Male or female
- •Patients with mucogingival defects scheduled for free gingival graft.
- •Patients with good oral hygiene.
排除标准
- •Patients with any uncontrolled local or systemic disease where periodontal plastic surgery might be contraindicated.
- •History of recent periodontal surgery at the donor site.
- •Pregnancy and lactation.
- •Patients allergic to the used agents,
- •Severe gagging reflex.
- •Inability or unwillingness to provide informed consent.
研究组 & 干预措施
curcumin gel
the denuded palatal area will be superficially covered with a continuous thin layer of curcumin gel 2% one time immediately after the surgery (curcumin gel will be prepared in 2% concentration on a carbapol base)according to (Bhatia et al., 2014)
干预措施: curcumin gel 2% (Other)
gelatine sponge
absorbable gelatin sponge will be cut to the palatal wound size and applied. Following manual compression of the wound area, both agents will be secured in place using compressive palatal sling sutures.
commercial name (CUTANPLAST)
干预措施: curcumin gel 2% (Other)
结局指标
主要结局
post-operative pain
时间窗: one week post operative
post -operative pain measured by visual analouge scale from 0 (no pain) to 10 (highest pain value)
次要结局
- Re-epithelization of the palatal wound(up to three weeks post-operative)
- Soft tissue healing of the palatal wound(up to three weeks post-operative)
研究者
Tansim Khaled Tawfik Abdelrahman
masters degree candidate
Cairo University