Comparison of efficacy of furosemide alone and albumin-furosemide combination for treatment of edema in nephrotic syndrome childre
- Conditions
- Health Condition 1: N040- Nephrotic syndrome with minor glomerular abnormality
- Registration Number
- CTRI/2022/09/045700
- Lead Sponsor
- Chacha Nehru Bal Chikitsalaya
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Children, between 1-12 years of age, with nephrotic syndrome and refractory edema ( <1% weight loss per day for 5 consecutive days or <5% cumulative weight loss by 5th day of hospitalization after receiving maximum oral dose of furosemide, hydrochlorothiazide or metolazone and IV furosemide bolus in sequence) will be enrolled for the study
1.Known secondary causes of nephrotic syndrome or with features of glomerulonephritis; like gross hematuria, hypertension, oliguria and deranged kidney function.
2.Children with acute diarrhoea
3.Clinical features of hypovolemia
4.With AKI stage II or III according to KDIGO definition and classification criteria for AKI
5.Children with severe systemic infections; like pneumonia, peritonitis, cellulitis or sepsis
6.Children with respiratory distress
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the mean difference in percentage weight loss at 24 hours in children with nephrotic syndrome and refractory edema receiving furosemide infusion in comparison to those receiving albumin-furosemide combinationTimepoint: 24 hours
- Secondary Outcome Measures
Name Time Method 1.Mean difference in percentage weight loss between two groups. <br/ ><br>Timepoint: at 48 and 72 hours of therapy