Physical Exercise in Hypertension, Randomised Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- 24 hour blood pressure
研究概览
简要总结
Endurance training has a documented effect on hypertension. However, only low to moderate training intensity has so far been studied. High aerobic intensity should, from physiological considerations, prove more effective in also reducing high blood pressure. The present study is a randomised comparison of high versus moderate intensity versus training in groups, and general advice on 24 hour blood pressure in hypertensives. The training period is 12 weeks, with follow-up after 1 year. Maximum oxygen uptake, quality of life, left ventricular function and blood vessel reactivity are also measured.
详细描述
Endurance training has documented effect on blood pressure in hypertension. However, only low to moderate training intensity has so far been studied. Higher aerobic intensity based on individual measurements of maximum oxygen uptake is more efficient in increasing oxygen uptake, and might prove more effective in lowering blood pressure. Group training, on the other hand is not individualised, but less personnel required and may prove more cost effective. Endurance training is shown to improve both systolic and diastolic left ventricular function, as well as endothelial function. Both can be measured non-invasively by ultrasound.
The study is an open, randomised study with four arms, comparing:
- High aerobic intensity interval training
- Moderate aerobic intensity training
- Group training
- Controls receiving standard advice on lifestyle and training
Training effect is measured by Max. Oxygen uptake, blood pressure by continuous 24 hour ambulatory measurement, Left ventricular function by echo Doppler and endothelial function by flow mediated vasodilation by ultrasound.
The effect of exercise on blood pressure is dependent on continued training. All patients will be followed up after one year.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Essential hypertension grade 1 - 2 without medical treatment
排除标准
- •End organ damage
- •Two or more cardiovascular risk factors
研究组 & 干预措施
AIT: aerobic interval training
High intensity interval training on treadmill at > 90% of maximal HR for four bouts of four minutes with warm up, active pauses and cool down, three times per week for 12 weeks.
干预措施: Aerobic interval training (Behavioral)
MIT, moderate intensity training
Moderate intensity treadmill continuous exercise at 70% of maximum heart rate for 47 minutes (in order to ensure isocaloric training amount), three times per week for 12 weeks.
干预措施: moderate intensity training (Behavioral)
Recommendation of regular exercise
No training intervention, general advice as prescribed in guidelines.
干预措施: Recommendation of regular exercise (Behavioral)
结局指标
主要结局
24 hour blood pressure
时间窗: 12 weeks
次要结局
- Maximum oxygen uptake(12 weeks)
- Endothelial function(12 weeks)
- Echocardiographic left ventricular function(12 weeks)
- Quality of life(12 weeks)