Early Diagnosis of Therapy-associated Cardiotoxicity Basing on Multi-tracer Multimodality PET/MRI
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- SUVR
研究概览
简要总结
Using Multi-tracer to early diagnosis of therapy-associated cardiotoxicity using multimodality PET/MRI.
详细描述
In this study investigators evaluated cardiac uptake by different molecular probe such as FDG, FAPI-04 using multimodality PET/MRI. Previous studies have shown that increased cardiac uptake of FDG on PET may be an indicator of myocardial injury after chemotherapy. Cardiac magnetic resonance (CMR) allows for multiparametric evaluation of cardiac morphology, ventricular function, myocardial perfusion, and viability. The combination of PET with MR (PET/MR) is therefore an alternative attractive pairing for diagnostic imaging. The aim of this study is to find noninvasive and effective method for early diagnosis of cardiotoxicity after chemotherapy or immunotherapy
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •availability of a clinical pre- and post-therapy clinical evaluation encompassing electrocardiogram (ECG) ;
- •normal findings at pre-therapy clinical evaluation;
- •cancer planned chemotherapy or immunotherapy scheme ;
- •available staging FDG-PET/CT scan (PET0);
排除标准
- •cannot lie supine for half an hour;
- •refuse to join the clinical researcher;
- •without metal implants.
结局指标
主要结局
SUVR
时间窗: 150 days
the ratio of the standardized uptake value(SUVR) of multi-tracer for the heart within each time window to that of the normal tissue such as hepatic blood pool、blood pool and gluteus.
次要结局
- Change Of Mapping Value and LVEF From Baseline(150 days)
研究者
Xuejuan Wang,MD
Principal Investigator
Peking University Cancer Hospital & Institute