New Biomarkers in the Prediction of Chemotherapy-induced Cardiotoxicity.

Recruiting

• Conditions: Chemotherapy Induced Systolic Dysfunction; Cardiotoxicity; Chemotherapy Effect

• Registration Number: NCT05992337
• Lead Sponsor: Cardiology Prague

Brief Summary

Early detection and thus rapid therapy of cardiotoxicity related to chemotherapy are essential for restoring cardiovascular function. The complete recovery of the cardiovascular system decreases with time to identify the presence of cardiotoxic damage. The project aims to define new biomarkers for the early detection of cardiotoxicity in patients treated with chemotherapy.

Detailed Description

The most effective approach to minimizing the consequences of cardiotoxicity of oncological treatment is its early identification, adjustment of oncological treatment (change of procedure, dose, drugs), and immediate initiation of cardiovascular therapy. However, the current standard for monitoring the cardiovascular system in cancer patients identifies cardiotoxicity only if functional impairment has already occurred, which precludes any chance of effective prevention. The aim of the project is to identify new biomarkers for the early detection of the cardiotoxic effect of chemotherapy in women with breast cancer.

Study Timeline

• Study Start: 2021-09-01
• Study First Submitted: 2021-09-28
• Status Verified: 2023-08
• Study First Submitted QC: 2023-08-07
• Study First Posted: 2023-08-15
• Last Update Submitted: 2023-08-15
• Last Update Posted: 2023-08-16
• Primary Completion: 2024-11
• Study Completion: 2025-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

• Breast cancer
• Chemotherapy with a known cardiotoxic side effect

Exclusion Criteria

• Known cardiovascular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Early detection of the cardiotoxic effect of chemotherapy using new biomarkers	one year follow-up.	Echocardiography and MRI detection of cardiotoxic effect of chemotherapy - dysfunction of left ventricle, arrythmias, hypertension

Trial Locations

Locations (2)

Cardiology Prague Ltd; 🇨🇿 Prague, Czechia

Oncology Center Medicon; 🇨🇿 Prague, Czechia