NCT00636844已完成不适用
Detection of Chemotherapy Induced Cardiotoxicity
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- The genetic profile of patients with anthracycline-induced elevation of troponin-I
研究概览
简要总结
To identify patients that are at risk of heart damage after receiving chemotherapy (adriamycin).
详细描述
To identify patients at risk of development of heart damage after receiving chemotherapy by obtaining the genetic profile of those who show: elevation of troponin, left ventricular systolic and diastolic dysfunction, and pro-oxidant stress markers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •undergoing anthracycline and/or trastuzumab therapy for the first time
排除标准
- •abnormal ventricular ejection fraction
- •past history of, or active cardiac disease including: MI, CHF, angina, arrhythmia requiring medication, valvular disease, uncontrolled systemic hypertension
结局指标
主要结局
The genetic profile of patients with anthracycline-induced elevation of troponin-I
时间窗: one year
次要结局
- Assess the genetic profile of patient with anthracycline-induced left ventricular systolic and diastolic dysfunction(one year)
- Assess the relationship of quantitative increases of pro-oxidant stress and a specific genetic profile(one year)
研究者
研究点 (1)
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