Early Markers of Radiation-Induced Cardiac Injury in Hodgkin Lymphoma Treated With Radiation Therapy

Completed

• Conditions: Hodgkin's Lymphoma
• Interventions: Procedure: Cardiac Magnetic Resonance Imaging; Procedure: Echocardiogram

• Registration Number: NCT02404818
• Lead Sponsor: University of Florida

Brief Summary

The purpose of this study is to evaluate if radiation and chemotherapy treatment cause cardiac abnormalities among survivors of Hodgkin's lymphoma.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-03-20
• Study First Submitted QC: 2015-03-26
• Study Start: 2015-04
• Study First Posted: 2015-04-01
• Primary Completion: 2021-04-14
• Study Completion: 2021-04-14
• Status Verified: 2022-06
• Last Update Submitted: 2022-06-09
• Last Update Posted: 2022-06-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

• Completed radiation and chemotherapy treatment for Hodgkin lymphoma involving the mediastinum.
• Patient must be ≥ 18 years at time of consent.

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Exclusion Criteria

• Pregnant women at time of Cardiac MRI
• Contraindications to Cardiac MRI (contrast allergy, metal implants, medical devices)
• Glomerular filtration rate (GFR) < 30, unless approved by Radiologist (UF Health Jacksonville Radiology Policy: Administration of Gadolinium-Based Contrast Agents).

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Survivors of Hodgkin's lymphoma	Cardiac Magnetic Resonance Imaging	Cardiac Magnetic Resonance Imaging and Echocardiogram
Survivors of Hodgkin's lymphoma	Echocardiogram	Cardiac Magnetic Resonance Imaging and Echocardiogram

Primary Outcome Measures

Name	Time	Method
Cardiac Abnormalities As Measured By Cardiac MRI	Day 1
Cardiac Abnormalities As Measured By Echocardiogram	Day 1

Trial Locations

Locations (1)

University of Florida Health Proton Therapy Institute; 🇺🇸 Jacksonville, Florida, United States