Ghrelin levels in patients with ACNES (Anterior Cutaneous Nerve Entrapment Syndrome) and gastrointestinal complaints, loss of appetite and weight loss.

Recruiting

• Conditions: ACNES (Anterior Cutaneous Nerve Entrapment Syndrome)

• Registration Number: NL-OMON25017
• Lead Sponsor: ot applicable.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Intervention group:
-diagnosed with ACNES
-at least two pseudovisceral complaints including loss of appetite related to pain and weight loss defined as: unintentional and more than 5% of usual body weight over at least 6 months
-age between 18 and 65
-receiving treatment for ACNES at our hospital
-obtained written informed consent

Control group:
-age between 18 and 65
-obtained written informed consent

Exclusion Criteria

Intervention group:
-BMI = 30 kg/m2
-recent intra-abdominal pathology
-history of bariatric surgery
-endocrine disease
-psychiatric disorder
-can’t obtain adequate follow-up
-pregnancy
-language barrier

Control group:
-BMI = 30 kg/m2
-ACNES
-weight loss over the last 6 months
-visceral complaints over the last month
-intra-abdominal pathology or surgery
-endocrine disease
-psychiatric disorder
-pregnancy
-language barrier

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The main study parameter is the difference in fasting ghrelin blood level between ACNES patients and a healthy control group.

Secondary Outcome Measures

Name	Time	Method
The secondary study parameters are:<br>•The difference in fasting ghrelin blood level before and after treatment for ACNES. <br>•The difference in fasting ghrelin blood level after treatment for ACNES between the ACNES patients with a successful therapy and those with a failed therapy.