Bicarbonates Versus Saline for Contrast Induced Acute Kidney Injury Prevention in Intensive Care Unit

Phase 3

Completed

• Conditions: Contrast Induced Acute Kidney Injury
• Interventions: Drug: bicarbonates; Drug: saline

• Registration Number: NCT01636089
• Lead Sponsor: University Hospital, Caen

Brief Summary

The aim of this study is to compare bicarbonates versus saline for prevention of contrast induced acute kidney injury in critically ill patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-02
• Study First Submitted: 2012-02-15
• Study First Submitted QC: 2012-07-05
• Study First Posted: 2012-07-10
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-02
• Last Update Posted: 2015-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• patient > 18 years old
• in intensive care unit since 24h and for up to 48 hours
• with contrast medium injection

Exclusion Criteria

• patient under renal replacement therapy
• rise in creatinine > 26µmol/L within 48hours
• anuria within 12 hours
• cardiogenic pulmonary oedema
• pH > 7.50 or kaliemia < 3mmol/L
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
bicarbonates	bicarbonates	sodium bicarbonates 1,4%
saline	saline	sodium chloride 0,9%

Primary Outcome Measures

Name	Time	Method
contrast induced acute kidney injury	72 hours

Trial Locations

Locations (3)

Medical Intensive Care Unit; 🇫🇷 Caen, France

Intensive care unit; 🇫🇷 Saint Lô, France

Surgical Intensive Care Unit; 🇫🇷 Caen, France