Prospective Randomised Study on the Safety of Non-invasive Ventilation Versus High-flow Oxygen in Patients With Hypoxemic Respiratory Failure Undergoing Fiberoptic Bronchoscopy.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Mean decrease in the saturation of oxygen (SpO2) during bronchoscopy.
研究概览
简要总结
Bronchoscopy with broncho-alveolar lavage is a diagnostic tool in patients with pneumonia. Especially patients with acute or chronic pulmonary diseases are at risk of respiratory failure during or after bronchoscopy. It is known that in these cases bronchoscopy can be performed safely using non-invasive ventilation. It seems probable that high-flow oxygen, which is used in the treatment of patients with hypoxemic respiratory failure, is equally effective in preventing the development of respiratory failure during fiberoptic bronchoscopy while improving patient comfort. In this prospective randomised study the safety of high-flow oxygen is compared with non-invasive ventilation in patients with hypoxemic respiratory failure undergoing fiberoptic bronchoscopy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients treated in an intensive care unit
- •indication for bronchoscopy and broncho-alveolar lavage
- •presence of hypoxemic (SaO2/fraction of inspired oxygen(FiO2): 300 or less) and/or hypercapnic respiratory failure
排除标准
- •patients already on invasive ventilation
- •indication for intubation
- •blocked nasopharynx
- •contraindications for non-invasive ventilation or high-flow oxygen
结局指标
主要结局
Mean decrease in the saturation of oxygen (SpO2) during bronchoscopy.
时间窗: during fiberoptic bronchoscopy
次要结局
- Changes in blood gases after the completion of fiberoptic bronchoscopy.(1 hour after the completion of bronchoscopy)
研究者
Stefan Kluge
PD Dr. Stefan Kluge
Universitätsklinikum Hamburg-Eppendorf