Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

Not Applicable

Completed

• Conditions: Blood Donation
• Interventions: Dietary Supplement: water; Drug: Oral Rehydration Salts power (iii); Dietary Supplement: water with white granulated sugar

• Registration Number: NCT05319951
• Lead Sponsor: Guangzhou Blood Center

Brief Summary

we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation

Detailed Description

Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar \& salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction.

However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.

Study Timeline

• Study First Submitted: 2020-12-01
• Study Start: 2021-01-20
• Primary Completion: 2021-11-26
• Study Completion: 2021-12-31
• Study First Submitted QC: 2022-04-07
• Study First Posted: 2022-04-11
• Status Verified: 2022-09
• Last Update Submitted: 2022-09-30
• Last Update Posted: 2022-10-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6250

Inclusion Criteria

All blood donors donated whole blood in Guangzhou Blood Center during study.

Exclusion Criteria

Blood donors who were deferral by blood screening result and other situations.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
recommended water intake	water	Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.
Oral Rehydration Salts Power (iii)	Oral Rehydration Salts power (iii)	Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.
water with white granulated sugar	water with white granulated sugar	Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Primary Outcome Measures

Name	Time	Method
vasovagal reaction rate	1-3days	vasovagal reaction rate in three groups

Secondary Outcome Measures

Name	Time	Method
rate of willingness to donate blood again	3days	rate of willingness to donate blood again in three groups

Trial Locations

Locations (1)

Guangzhou Blood Center; 🇨🇳 Guangzhou, Guangdong, China