Incidence and Risk Factors for Development of Epidermoid Carcinoma in Esophageal Achalasia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 681
- 试验地点
- 1
- 主要终点
- Detection of epidermoid carcinoma of the esophagus
研究概览
简要总结
Esophageal achalasia is a precancerous condition for epidermoid carcinoma; incidence and risk factors for cancer development are not defined. Incidence and risk factors for epidermoid carcinoma development in achalasia patients were investigated.
详细描述
In order to define incidence and risk factors for epidermoid carcinoma 681 patients affected by esophageal achalasia observed since 1973 were followed up with no time limits according to a prospective follow-up protocol. The local institutional review board approved using the database from the division of thoracic surgery for research purposes. Clinical, radiological and endoscopic data of achalasia patients were collected and analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of primary esophageal achalasia achieved by means of radiology, endoscopy and manometry
排除标准
- •pseudoachalasia
结局指标
主要结局
Detection of epidermoid carcinoma of the esophagus
时间窗: 1 year
Detection of epidermoid carcinoma of the esophagus by means of upper GI endoscopy
次要结局
- Result of achalasia treatment by investigating dysphagia and gastro-esophageal reflux(1 year)
研究者
Sandro Mattioli
Prof. Sandro Mattioli
University of Bologna