Effects of duloxetine(antidepressant)on pain after surgery in orthopaedic patients: A randomized controlled study
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2022/09/045631
- Lead Sponsor
- Kalinga Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Consenting patients >18 yrs of age
2) ASA I or II
3) Patients posted for orthopaedic surgeries like trauma, replacement, hip-replacement etc
Exclusion Criteria
1) Patients with known psychiatric illness or patients on antipsychotic medication
2) Allergy/intolerance to duloxetine
3) Patients on SSRIs, SNRIs, MAO inhibitors or recent use of MAO inhibitors ( <14 days), linezolid or if planned to be used in the post-operative period, methylene blue, triptans
4) Hypertensives on medication
5) Patients on anticoagulant therapy
6) Narrow angle glaucoma
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Static VAS score (VASs) and dynamic VAS score (VASd) four hourly on post-operative day 0, 1 and 2Timepoint: At 4 hourly intervals for 72 post-operative hours
- Secondary Outcome Measures
Name Time Method 1) Time for the first analgesic requirement. <br/ ><br>2) Amount of rescue analgesic required <br/ ><br>3) Number of doses of rescue analgesic required (tramadol and/or diclofenac) <br/ ><br>4) Incidence of post-operative nausea and vomiting <br/ ><br>5) Number of dressing pads changed due to soakageTimepoint: At 4 hourly internvals for 72 post-operative hours