Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty

Phase 4

• Conditions: Coronary Artery Disease

• Registration Number: NCT00262574
• Lead Sponsor: The Baruch Padeh Medical Center, Poriya

Brief Summary

Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients

Detailed Description

Not available

Study Timeline

• Study Start: 2005-07
• Study First Submitted: 2005-12-06
• Study First Submitted QC: 2005-12-06
• Study First Posted: 2005-12-07
• Status Verified: 2010-12
• Last Update Submitted: 2011-08-08
• Last Update Posted: 2011-08-09
• Primary Completion: 2012-04
• Study Completion: 2013-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

coronary artery disease -

Exclusion Criteria

CHF and/or reduced LV function, or renal failure with Creatinine >2mg%

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
FMD	3 years

Trial Locations

Locations (1)

The Baruch Pade medical center, Poriya; 🇮🇱 Tiberias, Israel