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Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty

Phase 4
Conditions
Coronary Artery Disease
Registration Number
NCT00262574
Lead Sponsor
The Baruch Padeh Medical Center, Poriya
Brief Summary

Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
500
Inclusion Criteria

coronary artery disease -

Exclusion Criteria

CHF and/or reduced LV function, or renal failure with Creatinine >2mg%

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Primary Outcome Measures
NameTimeMethod
FMD3 years
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

The Baruch Pade medical center, Poriya

🇮🇱

Tiberias, Israel

The Baruch Pade medical center, Poriya
🇮🇱Tiberias, Israel
Yonathan Hasin, Profesor
Principal Investigator

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