Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty
Phase 4
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT00262574
- Lead Sponsor
- The Baruch Padeh Medical Center, Poriya
- Brief Summary
Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 500
Inclusion Criteria
coronary artery disease -
Exclusion Criteria
CHF and/or reduced LV function, or renal failure with Creatinine >2mg%
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method FMD 3 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Baruch Pade medical center, Poriya
🇮🇱Tiberias, Israel