Expression of Optic Atrophy Type 1 (OPA1) Protein in Lung Adenocarcinoma
- Conditions
- Lung Adenocarcinoma
- Registration Number
- NCT01249053
- Lead Sponsor
- China Medical University Hospital
- Brief Summary
Optic atrophy type 1(OPA1) is a nuclear dynamin-related GTPase, targeted to the inner mitochondrial membrane, which plays a role in mitochondrial fusion. Mitochondria fusion is associated with process of apoptosis. . OPA1 plays an important role in the mitochondrial bioenergetics and mitochondrial networks. The changes in mitochondrial shape and mitochondrial bioenergetics may be cause of the disease. In this study, we investigate the expression of OPA1 in lung adenocarcinoma (LADC) cells and tissue.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- We will collect paraffin blocked resected lung tissue samples from stage I~IIIa non-small cell lung cancer patients (age, 40~80 years old) who received lobectomy of the affected lung.
Exclusion Criteria
- History of uremia, other malignant disease, and liver cirrhosis
- History of pneumonia and pulmonary tuberculosis
- History of long period of medications.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Fang Hsin Yuan
🇨🇳Taichung, Taiwan